CoCl2‐triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299

CoCl2‐triggered pseudohypoxic stress induces proteasomal degradation of SIRT4 via polyubiquitination of lysines K78 and K299

SIRT4, together with SIRT3 and SIRT5, comprises the mitochondrially localized subgroup of sirtuins. SIRT4 regulates mitochondrial bioenergetics, dynamics (mitochondrial fusion), and quality control (mitophagy) via its NAD+‐dependent enzymatic activities. Here, we address the regulation of SIRT4 itse...

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Bibliographic Details
Main Authors: Nils Hampel, Jacqueline Georgy, Mehrnaz Mehrabipour, Alexander Lang, Isabell Lehmkuhl, Jürgen Scheller, Mohammad R. Ahmadian, Doreen M. Floss, Roland P. Piekorz
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:FEBS Open Bio
Subjects:
autophagy
proteasome
pseudohypoxia
SIRT4
sirtuin
ubiquitination
Online Access:https://doi.org/10.1002/2211-5463.13715

Internet

https://doi.org/10.1002/2211-5463.13715

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