Prime editor‐mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS‐CoV‐2 variants

Prime editor‐mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS‐CoV‐2 variants

Abstract The spike protein of SARS‐CoV‐2 hijacks the host angiotensin converting enzyme 2 (ACE2) to meditate its entry and is the primary target for vaccine development. Nevertheless, SARS‐CoV‐2 keeps evolving and the latest Omicron subvariants BQ.1 and XBB have gained exceptional immune evasion pot...

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Bibliographic Details
Main Authors: Wenwen Zhao, Jifang Li, Xiao Wang, Wei Xu, Bao‐Qing Gao, Jiangchao Xiang, Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu, Li Yang, Jia Chen, Bei Yang
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:MedComm
Subjects:
broad spectrum
HCoV‐NL63
host factor reshaping
prime editing
SARS‐CoV
SARS‐CoV‐2 VOCs
Online Access:https://doi.org/10.1002/mco2.356

Internet

https://doi.org/10.1002/mco2.356

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