Differences across cyclophilin A orthologs contribute to the host range restriction of hepatitis C virus

The restricted host tropism of hepatitis C virus (HCV) remains incompletely understood, especially post-entry, and has hindered developing an immunocompetent, small animal model. HCV replication in non-permissive species may be limited by incompatibilities between the viral replication machinery and...

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Bibliographic Details
Main Authors: Jenna M Gaska, Metodi Balev, Qiang Ding, Brigitte Heller, Alexander Ploss
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/44436