A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the <i>Escherichia coli</i> Expression System

A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the <i>Escherichia coli</i> Expression System

T cell-mediated adaptive immunity plays a key role in immunological surveillance and host control of infectious diseases. A better understanding of T cell receptor (TCR) recognition of pathogen-derived epitopes or cancer-associated neoantigens is the basis for developing T cell-based vaccines and im...

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Bibliographic Details
Main Authors: Angela Zhang, Alicja Piechocka-Trocha, Xiaolong Li, Bruce D. Walker
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
T cell receptor
protein engineering
leucine zipper
<i>E. coli</i> expression
refolding
purification
Online Access:https://www.mdpi.com/2073-4409/11/3/312

Internet

https://www.mdpi.com/2073-4409/11/3/312

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