A randomized, single ascending dose safety, tolerability and pharmacokinetics study of NicaPlant® in aneurysmal subarachnoid hemorrhage patients undergoing clipping

A randomized, single ascending dose safety, tolerability and pharmacokinetics study of NicaPlant® in aneurysmal subarachnoid hemorrhage patients undergoing clipping

Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality. Post-hemorrhagic vasospasm with neurological deterioration is a major concern in this context. NicaPlant®, a modified release formulation of the calcium channel blocker nicardipine, has shown vas...

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Bibliographic Details
Main Authors: Johannes Kerschbaumer, Christian Franz Freyschlag, Ondra Petr, Tiziana Adage, Joerg Breitenbach J, Lars Wessels, Stefan Wolf, Nils Hecht, Jens Gempt, Maria Wostrack, Matthias Gmeiner, Maria Gollwitzer, Harald Stefanits, Martin Bendszus M, Andreas Gruber, Bernhard Meyer, Peter Vajkoczy, Claudius Thomé
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Brain and Spine
Subjects:
Aneurysm clipping
Aneurysmal subarachnoid hemorrhage
Cerebral vasospasm
Local delivery
Nicardipine
Online Access:http://www.sciencedirect.com/science/article/pii/S277252942300961X

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http://www.sciencedirect.com/science/article/pii/S277252942300961X

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