Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors

Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors

IntroductionCorticotroph pituitary neuroendocrine tumors (PitNETs) develop from ACTH-producing cells. They commonly cause Cushing’s disease (CD), however, some remain clinically silent. Recurrent USP8, USP48, BRAF and TP53 mutations occur in corticotroph PitNETs. The aim of our study was to determin...

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Bibliographic Details
Main Authors: Monika Pękul, Magdalena Szczepaniak, Paulina Kober, Natalia Rusetska, Beata J. Mossakowska, Szymon Baluszek, Artur Kowalik, Maria Maksymowicz, Grzegorz Zieliński, Jacek Kunicki, Przemysław Witek, Mateusz Bujko
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
corticotroph PitNET
Cushing’s disease
silent corticotroph tumor
USP8
USP48
BRAF
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1302667/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1302667/full

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