Fumarate Hydratase Enhances the Therapeutic Effect of PD-1 Antibody in Colorectal Cancer by Regulating PCSK9

Fumarate Hydratase Enhances the Therapeutic Effect of PD-1 Antibody in Colorectal Cancer by Regulating PCSK9

Despite the notable achievements of programmed death 1 (PD-1) antibodies in treating various cancers, the overall efficacy remains limited in the majority of colorectal cancer (CRC) cases. Metabolism reprogramming of tumors inhibits the tricarboxylic acid (TCA) cycle, leading to down-regulation of f...

Full description

Bibliographic Details
Main Authors: Le Qin, Liang Shi, Yu Wang, Haixin Yu, Zhouyuan Du, Mian Chen, Yuxuan Cai, Yinghao Cao, Shenghe Deng, Jun Wang, Denglong Cheng, Yixin Heng, Jiaxin Xu, Kailin Cai, Ke Wu
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
colorectal cancer
fumarate hydratase
immunotherapy
programmed cell death 1
protein invertase subtilisin/kexin 9 type
Online Access:https://www.mdpi.com/2072-6694/16/4/713

Internet

https://www.mdpi.com/2072-6694/16/4/713

Similar Items