A discrete-time split-state framework for multi-state modeling with application to describing the course of heart disease

Abstract In chronic disease epidemiology, the investigation of disease etiology has largely focused on an endpoint, while the course of chronic disease is understudied, representing a knowledge gap. Multi-state models can be used to describe the course of chronic disease, such as Markov models which...

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Bibliographic Details
Main Authors: Ming Ding, Haiyi Chen, Feng-Chang Lin
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-025-02512-6