L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

<p>Abstract</p> <p>Background</p> <p>In the central nervous system, astrocytic L-glutamate (L-Glu) transporters maintain extracellular L-Glu below neurotoxic levels, but their function is impaired with neuroinflammation. Microglia become activated with inflammation; how...

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Bibliographic Details
Main Authors: Takaki Junpei, Fujimori Koki, Miura Marie, Suzuki Takeshi, Sekino Yuko, Sato Kaoru
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
L-glutamate
Microglia
Transporter
Astrocytes
Inflammation
Hemichannel
Online Access:http://www.jneuroinflammation.com/content/9/1/275

Internet

http://www.jneuroinflammation.com/content/9/1/275

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