Gene duplication and deletion caused by over-replication at a fork barrier

Abstract Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair, aid bypass of DNA lesions, and enable replication restart, but may also pose a risk of over-replication during fork convergence. We show that...

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Bibliographic Details
Main Authors: Judith Oehler, Carl A. Morrow, Matthew C. Whitby
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43494-7