Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

Abstract Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. Methods We investiga...

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Bibliographic Details
Main Authors: Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert Barsotti, Lindon H. Young, Qian Chen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Pharmacology and Toxicology
Subjects:
Doxorubicin
Cardiotoxicity
Mitochondrial-targeted antioxidants
Vitamin C
Oxidative stress
Online Access:https://doi.org/10.1186/s40360-021-00518-6

Internet

https://doi.org/10.1186/s40360-021-00518-6

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