The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

SARS-CoV-2 pseudovirus infects human hepatocytes leading to metabolic reprogramming towards glycolysis and impaired mitochondrial activity, and metformin can reduce infection under steatotic conditions.

Bibliographic Details
Main Authors:	Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa Cardoso Delgado, Felix Elortza, Jesús Jiménez-Barbero, Ruben Nogueiras, Vincent Prevot, Asis Palazon, María L. Martínez-Chantar
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-08-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-022-03789-9

Internet

https://doi.org/10.1038/s42003-022-03789-9