A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

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Adhesion G protein-coupled receptors (aGPCRs) comprise the second largest yet least studied class of the GPCR superfamily. aGPCRs are involved in many developmental processes and immune and synaptic functions, but the mode of their signal transduction is unclear. Here, we show that a short peptide s...

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Bibliographic Details
Main Authors: Ines Liebscher, Julia Schön, Sarah C. Petersen, Liane Fischer, Nina Auerbach, Lilian Marie Demberg, Amit Mogha, Maxi Cöster, Kay-Uwe Simon, Sven Rothemund, Kelly R. Monk, Torsten Schöneberg
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471401002X

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http://www.sciencedirect.com/science/article/pii/S221112471401002X

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