Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout

Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout

CCR6 is a chemokine receptor highly implicated in inflammatory diseases and could be a potential therapeutic target; however, no therapeutic agents targeting CCR6 have progressed into clinical evaluation. Development of a high-throughput screening assay for CCR6 should facilitate the identification...

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Bibliographic Details
Main Authors: Sara Gómez-Melero, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Javier Caballero-Villarraso, Isaac Túnez, Elier Paz-Rojas
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
high-throughput screening
HTS
CCR6
hexosaminidase
calcium mobilization
cell-sensor
Online Access:https://www.mdpi.com/2227-9059/10/2/422

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https://www.mdpi.com/2227-9059/10/2/422

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