Autophagy Inhibition in Trophoblasts Induces Aberrant Shift in CXCR4<sup>+</sup> Decidual NK Cell Phenotype Leading to Pregnancy Loss

Autophagy Inhibition in Trophoblasts Induces Aberrant Shift in CXCR4<sup>+</sup> Decidual NK Cell Phenotype Leading to Pregnancy Loss

Background: Pregnancy, a complex biological phenomenon, relies on intricate maternal–fetal interactions for success. Decidual natural killer (dNK) cells and trophoblasts are pivotal in establishing immune tolerance at the maternal–fetal interface. The chemokine receptor CXCR4 plays a crucial role in...

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Bibliographic Details
Main Authors: Nan Liu, Huihui Shen, Zehua Wang, Xueyun Qin, Mingqing Li, Xinyan Zhang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Journal of Clinical Medicine
Subjects:
NK cells
trophoblast
autophagy
IGF2
pregnancy loss
CXCR4
Online Access:https://www.mdpi.com/2077-0383/12/23/7491

Internet

https://www.mdpi.com/2077-0383/12/23/7491

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