Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

Extracellular Vesicles From Gastric Cancer Cells Induce PD-L1 Expression on Neutrophils to Suppress T-Cell Immunity

Neutrophils are prominent components of solid tumors and exhibit distinct phenotypes in different tumor milieu. We have previously shown that tumor extracellular vesicles (EVs) could induce pro-tumor activation of neutrophils; however, the role of tumor EV-elicited neutrophils in tumor immunity rema...

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Bibliographic Details
Main Authors: Yinghong Shi, Jiahui Zhang, Zheying Mao, Han Jiang, Wei Liu, Hui Shi, Runbi Ji, Wenrong Xu, Hui Qian, Xu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
extracellular vesicles
programmed death-ligand 1 (PD-L1)
neutrophils
immune suppression
gastric cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00629/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00629/full

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