Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation

Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation

The synthesis of glycosyl-β-1<i>C</i>-(phosphino)-phosphonates is a challenge since it has not yet been described. In this paper, we report an innovative synthetic method for their preparation from Glc-, Man-, and Glc<i>N</i>Ac- lactone derivatives. The proposed original stra...

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Bibliographic Details
Main Authors: Michaël Bosco, Su-Jin Paik, Patricia Busca, Stuart E. H. Moore, Christine Gravier-Pelletier
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
<i>C</i>-glycoside
diphosphate analogs
phosphinophosphonate
alkaline diphosphatase
glycochemistry
Online Access:https://www.mdpi.com/1420-3049/25/21/4969

Internet

https://www.mdpi.com/1420-3049/25/21/4969

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