Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting

Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting

Abstract Steroidogenesis of gonadal cells is tightly regulated by gonadotropins. However, certain polycyclic aromatic hydrocarbons, including Benzo[a]pyrene (BaP), induce reproductive toxicity. Several existing studies have considered higher than environmentally relevant concentrations of BaP on mal...

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Bibliographic Details
Main Authors: Clara Lazzaretti, Neena Roy, Elia Paradiso, Chiara Capponi, Tommaso Ferrari, Francesca Reggianini, Samantha Sperduti, Carmela Perri, Lara Baschieri, Elisa Mascolo, Manuela Varani, Giulia Canu, Tommaso Trenti, Alessia Nicoli, Daria Morini, Francesca Iannotti, Maria Teresa Villani, Elena Vicini, Manuela Simoni, Livio Casarini
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51516-7

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https://doi.org/10.1038/s41598-024-51516-7

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