The structural basis of the multi-step allosteric activation of Aurora B kinase

The structural basis of the multi-step allosteric activation of Aurora B kinase

Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the...

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Bibliographic Details
Main Authors: Dario Segura-Peña, Oda Hovet, Hemanga Gogoi, Jennine Dawicki-McKenna, Stine Malene Hansen Wøien, Manuel Carrer, Ben E Black, Michele Cascella, Nikolina Sekulic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
protein kinase
cell division
conformational dynamics
allostery
autoactivation
Aurora B
Online Access:https://elifesciences.org/articles/85328

Internet

https://elifesciences.org/articles/85328

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