Protective immunity induced by peptides of AMA1, RON2 and RON4 containing T-and B-cell epitopes via an intranasal route against toxoplasmosis in mice

Protective immunity induced by peptides of AMA1, RON2 and RON4 containing T-and B-cell epitopes via an intranasal route against toxoplasmosis in mice

Abstract Background Toxoplasma gondii is a ubiquitous protozoan intracellular parasite, the causative agent of toxoplasmosis, and a worldwide zoonosis. Apical membrane antigen-1 (AMA1) and rhoptry neck protein (RON2, RON4) are involved in the invasion of T. gondii. Methods This study chemically synt...

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Bibliographic Details
Main Authors: Tie-E Zhang, Li-Tian Yin, Run-Hua Li, Hai-Long Wang, Xiao-Li Meng, Guo-Rong Yin
Format: Article
Language:English
Published: BMC 2015-01-01
Series:Parasites & Vectors
Subjects:
Toxoplasma gondii
AMA1
RON2
RON4
Peptide epitope
Mucosal vaccine
Online Access:https://doi.org/10.1186/s13071-015-0636-5

Internet

https://doi.org/10.1186/s13071-015-0636-5

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