Proline–Proline Dyad in the Fusion Peptide of the Murine β–Coronavirus Spike Protein’s S2 Domain Modulates Its Neuroglial Tropism

Proline–Proline Dyad in the Fusion Peptide of the Murine β–Coronavirus Spike Protein’s S2 Domain Modulates Its Neuroglial Tropism

The β-Coronavirus mouse hepatitis virus (MHV-A59)-RSA59 has a patent stretch of fusion peptide (FP) containing two consecutive central prolines (PP) in the S2 domain of the Spike protein. Our previous studies compared the PP-containing fusogenic-demyelinating strain RSA59(PP) to its one proline-dele...

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Bibliographic Details
Main Authors: Abass Alao Safiriyu, Vaishali Mulchandani, Mohammed Nahaf Anakkacheri, Debnath Pal, Jayasri Das Sarma
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
β-coronavirus
recombinant strain mouse hepatitis virus-A59/RSA59
recombinant strain MHV-2/RSMHV2
Spike protein
fusion peptide (FP)
fusion-mutant strain RSA59(P)
Online Access:https://www.mdpi.com/1999-4915/15/1/215

Internet

https://www.mdpi.com/1999-4915/15/1/215

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