Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit.

Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit.

BACKGROUND: Mice, whose ribosomal protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P-/-)), are viable and fertile. However, phenotypic characterization of these mice and embryo fibroblasts derived from them, has established the rol...

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Bibliographic Details
Main Authors: Igor Ruvinsky, Maximiliano Katz, Avigail Dreazen, Yuval Gielchinsky, Ann Saada, Nanette Freedman, Eyal Mishani, Gabriel Zimmerman, Judith Kasir, Oded Meyuhas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2682700?pdf=render

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http://europepmc.org/articles/PMC2682700?pdf=render

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