Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition

Abstract Numerous myofibroblasts are arisen from endothelial cells (ECs) through endothelial to mesenchymal transition (EndMT) triggered by TGF-β. However, the mechanism of ECs transforms to a different subtype, or whether there exists an intermediate state of ECs remains unclear. In present study,...

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Bibliographic Details
Main Authors: Cuidi Xu, Juntao Chen, Lifei Liang, Siyue Chen, Xinhao Niu, Ruirui Sang, Cheng Yang, Ruiming Rong
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06154-0