Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data

Identifying Antidepressant Effects of Brain-Derived Neurotrophic Factor and IDO1 in the Mouse Model Based on RNA-Seq Data

Deletion of brain-derived neurotrophic factor (BDNF) and upregulation of indoleamine 2,3-dioxygenase 1 (IDO1) are associated with depression severity in animals. The neurotransmitter hypothesis of depression at the transcriptomic level can be tested using BDNF- and IDO1-knockout mouse models and RNA...

Full description

Bibliographic Details
Main Authors: Jing Ren, Chenyang Li, Songren Wei, Yanjun He, Peng Huang, Jiangping Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Genetics
Subjects:
depression
RNA-seq
pathway enrichment analysis
protein–protein interaction (PPI) network
brain-derived neurotrophic factor (BDNF)
indoleamine 2,3-dioxygenase 1 (IDO1)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.890961/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.890961/full

Similar Items