Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4

Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4

The size, conformation, and organization of the glycosaminoglycan hyaluronan (HA) affect its interactions with soluble and cell surface-bound proteins. HA that is induced to form stable networks has unique biological properties relative to unmodified soluble HA. AlphaLISA assay technology offers a f...

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Bibliographic Details
Main Authors: Yun Jin Ashley Sin, Rebecca MacLeod, Adam P. Tanguay, Andrew Wang, Olivia Braender-Carr, Teraesa M. Vitelli, Gregory D. Jay, Tannin A. Schmidt, Mary K. Cowman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
hyaluronan
TSG-6
PRG4
lubricin
heparin
heparan sulfate
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.990861/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.990861/full

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