Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4

Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4

The size, conformation, and organization of the glycosaminoglycan hyaluronan (HA) affect its interactions with soluble and cell surface-bound proteins. HA that is induced to form stable networks has unique biological properties relative to unmodified soluble HA. AlphaLISA assay technology offers a f...

Full description

Bibliographic Details
Main Authors:	Yun Jin Ashley Sin, Rebecca MacLeod, Adam P. Tanguay, Andrew Wang, Olivia Braender-Carr, Teraesa M. Vitelli, Gregory D. Jay, Tannin A. Schmidt, Mary K. Cowman
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Molecular Biosciences
Subjects:	hyaluronan TSG-6 PRG4 lubricin heparin heparan sulfate
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.990861/full

Similar Items

Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in <i>Prg4</i> Null Mice
by: Daniel S. Yang, et al.
Published: (2022-04-01)

Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells
by: Nikhil G. Menon, et al.
Published: (2022-10-01)

Hyaluronan Accelerates Intestinal Mucosal Healing through Interaction with TSG-6
by: Giusy Sammarco, et al.
Published: (2019-09-01)

PRG3 and PRG5 C-Termini: Important Players in Early Neuronal Differentiation
by: Nicola Brandt, et al.
Published: (2022-10-01)

Protective Effects of a Hyaluronan-Binding Peptide (P15-1) on Mesenchymal Stem Cells in an Inflammatory Environment
by: Thorsten Kirsch, et al.
Published: (2021-06-01)

Densification: Hyaluronan Aggregation in Different Human Organs
by: Antonio Stecco, et al.
Published: (2022-04-01)

Bond strength of composite resin containing biomaterial S-PRG to eroded dentin
by: Alessandra Sanchez Coelho Lourenço, et al.
Published: (2017-12-01)

Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears
by: Solaiman Tarafder, et al.
Published: (2023-10-01)

PXL01 in sodium hyaluronate results in increased PRG4 expression: a potential mechanism for anti-adhesion
by: Sara Edsfeldt, et al.
Published: (2017-01-01)

Heparin, Heparan Sulphate and Sepsis: Potential New Options for Treatment
by: John Hogwood, et al.
Published: (2023-02-01)

S-PRG Filler Eluate Induces Oxidative Stress in Oral Microorganism: Suppression of Growth and Pathogenicity, and Possible Clinical Application
by: Yu Kono, et al.
Published: (2021-07-01)

Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars
by: Katarzyna A. Uniewicz, et al.
Published: (2014-06-01)

Tumor Necrosis Factor (TNF)-α-Stimulated Gene 6 (TSG-6): A Promising Immunomodulatory Target in Acute Neurodegenerative Diseases
by: Daniele La Russa, et al.
Published: (2023-01-01)

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors
by: Ha Na Kim, et al.
Published: (2017-05-01)

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation
by: Mathijs G.A. Broeren, et al.
Published: (2018-05-01)

Dexamethasone Inhibits Heparan Sulfate Biosynthetic System and Decreases Heparan Sulfate Content in Orthotopic Glioblastoma Tumors in Mice
by: Dmitry K. Sokolov, et al.
Published: (2023-06-01)

Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4)
by: Marwa M. Qadri
Published: (2023-10-01)

Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care
by: Satoshi Imazato, et al.
Published: (2023-04-01)

Novel Tsg101 Binding Partners Regulate Viral L Domain Trafficking
by: Madeleine Strickland, et al.
Published: (2021-06-01)

RNA Binding Suppresses Tsg101 Recognition of Ub-Modified Gag and Facilitates Recruitment to the Plasma Membrane
by: Susan M. Watanabe, et al.
Published: (2020-04-01)

A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function
by: Yukiko Ota, et al.
Published: (2022-02-01)

Heparan sulfates and heparan sulfate binding proteins in sepsis
by: Yi-En Liao, et al.
Published: (2023-02-01)

The Relationship between TSG101 Protein and Notch3 Receptor in Lung Cancer
by: Jiahui CHANG, et al.
Published: (2009-02-01)

Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells
by: Jia Shi, et al.
Published: (2022-05-01)

Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled
by: Theodoros Karalis
Published: (2023-12-01)

Analysis of the Expression of LSF Transcription Factor in the Regulation of Transcription and TSG101 during the Neoplastic Transformation of Endometrial Cells
by: Rafał Ziemiński, et al.
Published: (2024-03-01)

Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy
by: Aikaterini Berdiaki, et al.
Published: (2021-03-01)

Interaction of TSG101 with the PTAP Motif in Distinct Locations of Gag Determines the Incorporation of HTLV-1 Env into the Retroviral Virion
by: Yosuke Maeda, et al.
Published: (2023-11-01)

The Neuroprotective Effects of Exosomes Derived from TSG101-Overexpressing Human Neural Stem Cells in a Stroke Model
by: Eun-Jung Yoon, et al.
Published: (2022-08-01)

Regulatory Mechanisms of <i>Prg4</i> and <i>Gdf5</i> Expression in Articular Cartilage and Functions in Osteoarthritis
by: Yoshifumi Takahata, et al.
Published: (2022-04-01)

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells
by: Heikki Kyykallio, et al.
Published: (2020-07-01)

What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype
by: Anthony J. Hayes, et al.
Published: (2021-04-01)

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican
by: Jiapeng Xue, et al.
Published: (2020-07-01)

Adhesive Properties of the Hyaluronan Pericellular Coat in Hyaluronan Synthases Overexpressing Mesenchymal Stem Cells
by: Sebastian Reiprich, et al.
Published: (2020-05-01)

Heparan Sulfate Proteoglycans in Tauopathy
by: Yanan Zhu, et al.
Published: (2022-11-01)

Tsg101 Is Involved in the Sorting and Re-Distribution of Glucose Transporter-4 to the Sarcolemma Membrane of Cardiac Myocytes
by: Kobina Essandoh, et al.
Published: (2020-08-01)

Hyaluronan and Collagen Are Prominent Extracellular Matrix Components in Bovine and Porcine Ovaries
by: Wendena S. Parkes, et al.
Published: (2021-07-01)

Role of TGF-β and p38 MAPK in TSG-6 Expression in Adipose Tissue-Derived Stem Cells In Vitro and In Vivo
by: Hye Youn Kwon, et al.
Published: (2023-12-01)

Significant Remodeling Affects the Circulating Glycosaminoglycan Profile in Adult Patients with both Severe and Mild Forms of Acute Pancreatitis
by: Ewa M. Koźma, et al.
Published: (2020-05-01)

Ovarian Cancer-Cell Pericellular Hyaluronan Deposition Negatively Impacts Prognosis of Ovarian Cancer Patients
by: Leticia Oliveira-Ferrer, et al.
Published: (2022-11-01)