Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition

Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition

Abstract Background Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality. Therapy resistance and significant side effects of current treatment strategies indicate the need for more effective agents to treat bo...

Full description

Bibliographic Details
Main Authors: Achinto Saha, Shengyuan Zhao, Austin Kindall, Carly Wilder, Chelsea A. Friedman, Rachel Clark, George Georgiou, Everett Stone, Dawit Kidane, John DiGiovanni
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
Reactive Oxygen Species
DNA damage
Combination therapy
Immune checkpoint inhibitor
Online Access:https://doi.org/10.1186/s13046-023-02677-2

Internet

https://doi.org/10.1186/s13046-023-02677-2

Similar Items