Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of <i>DPYD</i> Exon Sequencing and the Role of Phenotyping Assays

Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of <i>DPYD</i> Exon Sequencing and the Role of Phenotyping Assays

Deficiency of dihydropyrimidine dehydrogenase (DPD), encoded by the <i>DPYD</i> gene, is associated with severe toxicity induced by the anti-cancer drug 5-Fluorouracil (5-FU). <i>DPYD</i> genotyping of four recommended polymorphisms is widely used to predict toxicity, yet the...

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Bibliographic Details
Main Authors: Ottavia De Luca, Gerardo Salerno, Donatella De Bernardini, Maria Simona Torre, Maurizio Simmaco, Luana Lionetto, Giovanna Gentile, Marina Borro
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
5-fluorouracil
<i>DPYD</i>
dihydropyrimidine dehydrogenase
next generation sequencing
polymorphism
phenotyping
Online Access:https://www.mdpi.com/1422-0067/23/22/13923

Internet

https://www.mdpi.com/1422-0067/23/22/13923

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