PKCθ Regulates Pituitary Adenoma Bone Invasion by Activating Osteoclast in NF-κB/IL-1β-Dependent Manner

PKCθ Regulates Pituitary Adenoma Bone Invasion by Activating Osteoclast in NF-κB/IL-1β-Dependent Manner

Background: Pituitary adenoma (PA) bone invasion results in adverse outcomes, such as reduced rates of complete surgical resection and biochemical remission as well as increased recurrence rates, though few studies have been conducted. Methods: We collected clinical specimens of PAs for staining and...

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Bibliographic Details
Main Authors: Quanji Wang, Zhuowei Lei, Zihan Wang, Qian Jiang, Zhuo Zhang, Xiaojin Liu, Biao Xing, Sihan Li, Xiang Guo, Yanchao Liu, Xingbo Li, Kai Shu, Huaqiu Zhang, Yimin Huang, Ting Lei
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
pituitary adenomas
PKCtheta
macrophage
osteoclasts
bone invasion
celastrol
Online Access:https://www.mdpi.com/2072-6694/15/5/1624

Internet

https://www.mdpi.com/2072-6694/15/5/1624

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