Structural Analysis of Sortase A Inhibitors

Structural Analysis of Sortase A Inhibitors

Bacterial sortases are cysteine transpeptidases that regulate the covalent linkage of several surface protein virulence factors in Gram-positive bacteria. Virulence factors play significant roles in adhesion, invasion of host tissues, biofilm formation and immune evasion, mediating the bacterial pat...

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Bibliographic Details
Main Authors: Georgiana Nitulescu, Anca Zanfirescu, Octavian Tudorel Olaru, Isabela Madalina Nicorescu, George Mihai Nitulescu, Denisa Margina
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Molecules
Subjects:
cysteine transpeptidases
anti-virulence drugs
Gram-positive bacteria
classification method
rotatable bonds
hydrogen bond acceptors
Bemis-Murcko scaffolding
Online Access:http://www.mdpi.com/1420-3049/21/11/1591

Internet

http://www.mdpi.com/1420-3049/21/11/1591

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