An Imbalance in Histone Modifiers Induces tRNA-Cys-GCA Overexpression and tRF-27 Accumulation by Attenuating Promoter H3K27me3 in Primary Trastuzumab-Resistant Breast Cancer

An Imbalance in Histone Modifiers Induces tRNA-Cys-GCA Overexpression and tRF-27 Accumulation by Attenuating Promoter H3K27me3 in Primary Trastuzumab-Resistant Breast Cancer

tRNA-derived fragments (tRFs) play crucial roles in cancer progression. Among them, tRF-27 has been identified as a key factor in promoting <i>naïve</i> trastuzumab resistance in HER2-positive breast cancer. However, the origin of tRF-27 remains uncertain. In this study, we propose that...

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Bibliographic Details
Main Authors: Ningjun Duan, Yijia Hua, Xueqi Yan, Yaozhou He, Tianyu Zeng, Jue Gong, Ziyi Fu, Wei Li, Yongmei Yin
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cancers
Subjects:
breast cancer
trastuzumab resistance
tRNA derived fragments
tRNA transcription
histone modification
Online Access:https://www.mdpi.com/2072-6694/16/6/1118

Internet

https://www.mdpi.com/2072-6694/16/6/1118

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