Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Abstract The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post-transcriptional regulator of SREBP activation. Constitutive or inducible global ablation of Spring in mice is not tole...

Full description

Bibliographic Details
Main Authors: Sebastian Hendrix, Jenina Kingma, Roelof Ottenhoff, Masoud Valiloo, Monika Svecla, Lobke F. Zijlstra, Vinay Sachdev, Kristina Kovac, Johannes H. M. Levels, Aldo Jongejan, Jan F. de Boer, Folkert Kuipers, Antoine Rimbert, Giuseppe D. Norata, Anke Loregger, Noam Zelcer
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40943-1

Internet

https://doi.org/10.1038/s41467-023-40943-1

Similar Items