Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity

G protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein interface and that promiscuous GPCRs more frequently s...

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Bibliographic Details
Main Authors: Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H. Lee, David E. Gloriam, Stéphane A. Laporte, M. Madan Babu, Nagarajan Vaidehi
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34055-5

Internet

https://doi.org/10.1038/s41467-022-34055-5

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