Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity
G protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein interface and that promiscuous GPCRs more frequently s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34055-5 |
| _version_ | 1811315523216998400 |
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| author | Manbir Sandhu Aaron Cho Ning Ma Elizaveta Mukhaleva Yoon Namkung Sangbae Lee Soumadwip Ghosh John H. Lee David E. Gloriam Stéphane A. Laporte M. Madan Babu Nagarajan Vaidehi |
| author_facet | Manbir Sandhu Aaron Cho Ning Ma Elizaveta Mukhaleva Yoon Namkung Sangbae Lee Soumadwip Ghosh John H. Lee David E. Gloriam Stéphane A. Laporte M. Madan Babu Nagarajan Vaidehi |
| author_sort | Manbir Sandhu |
| collection | DOAJ |
| description | G protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein interface and that promiscuous GPCRs more frequently sample the common rather than selective contacts. |
| first_indexed | 2024-04-13T11:32:49Z |
| format | Article |
| id | doaj.art-3f58c0dca0e94af083460b63eb5f6506 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T11:32:49Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3f58c0dca0e94af083460b63eb5f65062022-12-22T02:48:32ZengNature PortfolioNature Communications2041-17232022-12-0113111410.1038/s41467-022-34055-5Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuityManbir Sandhu0Aaron Cho1Ning Ma2Elizaveta Mukhaleva3Yoon Namkung4Sangbae Lee5Soumadwip Ghosh6John H. Lee7David E. Gloriam8Stéphane A. Laporte9M. Madan Babu10Nagarajan Vaidehi11Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Medicine, Research Institute of the McGill University Health CentreDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Medicine, Research Institute of the McGill University Health CentreDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Medicine, Research Institute of the McGill University Health CentreDepartment of Structural Biology, Center for Data Driven Discovery, St. Jude Children’s Research HospitalDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of HopeG protein coupled receptors (GPCRs) can couple to different Gα protein subfamilies either selectively or promiscuously. Here, the authors use computational approach to show that selectivity determinants are at the periphery of the GPCR—G protein interface and that promiscuous GPCRs more frequently sample the common rather than selective contacts.https://doi.org/10.1038/s41467-022-34055-5 |
| spellingShingle | Manbir Sandhu Aaron Cho Ning Ma Elizaveta Mukhaleva Yoon Namkung Sangbae Lee Soumadwip Ghosh John H. Lee David E. Gloriam Stéphane A. Laporte M. Madan Babu Nagarajan Vaidehi Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity Nature Communications |
| title | Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity |
| title_full | Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity |
| title_fullStr | Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity |
| title_full_unstemmed | Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity |
| title_short | Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity |
| title_sort | dynamic spatiotemporal determinants modulate gpcr g protein coupling selectivity and promiscuity |
| url | https://doi.org/10.1038/s41467-022-34055-5 |
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