Neuronal SNCA transcription during Lewy body formation

Neuronal SNCA transcription during Lewy body formation

Abstract Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’s disease. A contradictory concept p...

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Bibliographic Details
Main Authors: Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Acta Neuropathologica Communications
Subjects:
α-Synuclein
Lewy body disease
mRNA
Parkinson’s disease
Proteinopathy
Proteinopenia
Online Access:https://doi.org/10.1186/s40478-023-01687-7

Internet

https://doi.org/10.1186/s40478-023-01687-7

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