Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives

Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives

The styryl dye FM1-43 is widely used to study endocytosis but behaves as a permeant blocker of the mechano-electrical transducer (MET) channel in sensory hair cells, loading rapidly and specifically into the cytoplasm of hair cells in a MET channel-dependent manner. Patch clamp recordings of mouse o...

Full description

Bibliographic Details
Main Authors: Marco Derudas, Molly O’Reilly, Nerissa K. Kirkwood, Emma J. Kenyon, Sybil Grimsey, Siân R. Kitcher, Shawna Workman, James C. Bull, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
FM1-43
mechano-electrical transducer channel
hair cell
zebrafish
hearing
ototoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1247324/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1247324/full

Similar Items