Multiple ETS Factors Participate in the Transcriptional Control of <i>TERT</i> Mutant Promoter in Thyroid Cancers

Multiple ETS Factors Participate in the Transcriptional Control of <i>TERT</i> Mutant Promoter in Thyroid Cancers

Hotspot mutations in the <i>TERT</i> (telomerase reverse transcriptase) gene are key determinants of thyroid cancer progression. <i>TERT</i> promoter mutations (TPM) create de novo consensus binding sites for the ETS (“E26 transformation specific”) family of transcription fac...

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Bibliographic Details
Main Authors: Caitlin E. M. Thornton, Jingzhu Hao, Prasanna P. Tamarapu, Iñigo Landa
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
<i>TERT</i> promoter mutations
ETS factors
thyroid cancer
transcriptional regulation
MAPK signaling
Online Access:https://www.mdpi.com/2072-6694/14/2/357

Internet

https://www.mdpi.com/2072-6694/14/2/357

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