Enantiotropy of Simvastatin as a Result of Weakened Interactions in the Crystal Lattice: Entropy-Driven Double Transitions and the Transient Modulated Phase as Seen by Solid-State NMR Spectroscopy

Enantiotropy of Simvastatin as a Result of Weakened Interactions in the Crystal Lattice: Entropy-Driven Double Transitions and the Transient Modulated Phase as Seen by Solid-State NMR Spectroscopy

In crystalline molecular solids, in the absence of strong intermolecular interactions, entropy-driven processes play a key role in the formation of dynamically modulated transient phases. Specifically, in crystalline simvastatin, the observed fully reversible enantiotropic behavior is associated wit...

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Bibliographic Details
Main Authors: Jiri Brus, Jiri Czernek, Martina Urbanova, Ctirad Červinka
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
polymorphism
enantiotropy
transient modulated phase
dynamics
entropy
solid-state nuclear magnetic resonance (NMR)
Online Access:https://www.mdpi.com/1420-3049/27/3/679

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https://www.mdpi.com/1420-3049/27/3/679

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