Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Strain-Dependent Impact of G and SH Deletions Provide New Insights for Live-Attenuated HMPV Vaccine Development

Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and/or G protein deletions. This approach showed p...

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Bibliographic Details
Main Authors: Julia Dubois, Andrés Pizzorno, Marie-Hélène Cavanagh, Blandine Padey, Claire Nicolas de Lamballerie, Olus Uyar, Marie-Christine Venable, Julie Carbonneau, Aurélien Traversier, Thomas Julien, Sophie Lavigne, Christian Couture, Bruno Lina, Marie-Ève Hamelin, Olivier Terrier, Manuel Rosa-Calatrava, Guy Boivin
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Vaccines
Subjects:
human metapneumovirus (hmpv)
live-attenuated vaccine (lav)
g protein
sh protein
gene deletion
reverse genetics
Online Access:https://www.mdpi.com/2076-393X/7/4/164

Internet

https://www.mdpi.com/2076-393X/7/4/164

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