A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.

Bibliographic Details
Main Authors: Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling, Amiya Kumar Patra
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11841

Internet

https://doi.org/10.1038/ncomms11841

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