A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11841 |
| _version_ | 1818842114430074880 |
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| author | Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra |
| author_facet | Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra |
| author_sort | Stefan Klein-Hessling |
| collection | DOAJ |
| description | NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1. |
| first_indexed | 2024-12-19T04:36:50Z |
| format | Article |
| id | doaj.art-3f649647fbdd4d0799d4dc0597425c49 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:36:50Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3f649647fbdd4d0799d4dc0597425c492022-12-21T20:35:43ZengNature PortfolioNature Communications2041-17232016-06-017111410.1038/ncomms11841A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia developmentStefan Klein-Hessling0Ronald Rudolf1Khalid Muhammad2Klaus-Peter Knobeloch3Muhammad Ahmad Maqbool4Pierre Cauchy5Jean-Christophe Andrau6Andris Avots7Claudio Talora8Volker Ellenrieder9Isabella Screpanti10Edgar Serfling11Amiya Kumar Patra12Department of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Pathology, Institute of Neuropathology, University Clinic FreiburgInstitute de Génétique Moléculaire de Montpellier (IGMM)Institute of Biomedical Research, College of Medical and Dental Sciences, University of BirminghamInstitute de Génétique Moléculaire de Montpellier (IGMM)Department of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of RomeDepartment of Gastroenterology II, University of GoettingenDepartment of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of RomeDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgNFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.https://doi.org/10.1038/ncomms11841 |
| spellingShingle | Stefan Klein-Hessling Ronald Rudolf Khalid Muhammad Klaus-Peter Knobeloch Muhammad Ahmad Maqbool Pierre Cauchy Jean-Christophe Andrau Andris Avots Claudio Talora Volker Ellenrieder Isabella Screpanti Edgar Serfling Amiya Kumar Patra A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development Nature Communications |
| title | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_full | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_fullStr | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_full_unstemmed | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_short | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development |
| title_sort | threshold level of nfatc1 activity facilitates thymocyte differentiation and opposes notch driven leukaemia development |
| url | https://doi.org/10.1038/ncomms11841 |
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