Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells

Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells

Abstract Inflammasomes are multiprotein platforms responsible for the release of pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Mouse studies have identified inflammasome activation within dendritic cells (DC) as pivotal for driving tubulointerstitial fibrosis and inflammation, the hallma...

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Bibliographic Details
Main Authors: Kurt T. K. Giuliani, Anca Grivei, Purba Nag, Xiangju Wang, Melissa Rist, Katrina Kildey, Becker Law, Monica S. Ng, Ray Wilkinson, Jacobus Ungerer, Josephine M. Forbes, Helen Healy, Andrew J. Kassianos
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05191-z

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https://doi.org/10.1038/s41419-022-05191-z

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