Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the mitochondria. GOT2 is a key component of mutant KRAS (KRAS*)-mediated rewiring of glutamine metabolism in pancreatic du...
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Materiálatiipa: | Artihkal |
Giella: | English |
Almmustuhtton: |
eLife Sciences Publications Ltd
2022-07-01
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Ráidu: | eLife |
Fáttát: | |
Liŋkkat: | https://elifesciences.org/articles/73245 |