Molecular characterization of gliomas and glioneuronal tumors amid Noonan syndrome: cancer predisposition examined

Molecular characterization of gliomas and glioneuronal tumors amid Noonan syndrome: cancer predisposition examined

IntroductionIn the setting of pediatric and adolescent young adult cancer, increased access to genomic profiling has enhanced the detection of genetic variation associated with cancer predisposition, including germline syndromic conditions. Noonan syndrome (NS) is associated with the germline RAS pa...

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Main Authors: Margaret Shatara, Kathleen M. Schieffer, Marilena Melas, Elizabeth A. Varga, Diana Thomas, Brianna A. Bucknor, Heather M. Costello, Gregory Wheeler, Benjamin J. Kelly, Katherine E. Miller, Diana P. Rodriguez, Mariam T. Mathew, Kristy Lee, Erin Crotty, Sarah Leary, Vera A. Paulson, Bonnie Cole, Mohamed S. Abdelbaki, Jonathan L. Finlay, Margot A. Lazow, Ralph Salloum, Maryam Fouladi, Daniel R. Boué, Elaine R. Mardis, Catherine E. Cottrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Oncology
Subjects:
glioma
glioneuronal tumor
Noonan syndrome
cancer predisposition
PTPN11
germline
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1453309/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1453309/full

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