Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in Enterococcus faecalis

Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in Enterococcus faecalis

Conjugation is a major mechanism that facilitates the exchange of antibiotic resistance genes among bacteria. The broad-host-range Inc18 plasmid pIP501 harbors 15 genes that encode for a type IV secretion system (T4SS). It is a membrane-spanning multiprotein complex formed between conjugating donor...

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Bibliographic Details
Main Authors: Claudia Michaelis, Tamara M. I. Berger, Kirill Kuhlmann, Rangina Ghulam, Lukas Petrowitsch, Maria Besora Vecino, Bernd Gesslbauer, Tea Pavkov-Keller, Walter Keller, Elisabeth Grohmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
type IV secretion system
antibiotic resistance
conjugative transfer
pIP501
Enterococcus faecalis
transfer regulator
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1268647/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1268647/full

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