25-Hydroxycholesterol Mediates Cholesterol Metabolism to Restrict Porcine Deltacoronavirus Infection via Suppression of Transforming Growth Factor β1

25-Hydroxycholesterol Mediates Cholesterol Metabolism to Restrict Porcine Deltacoronavirus Infection via Suppression of Transforming Growth Factor β1

ABSTRACT Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus in pigs, is one of the major pathogens for lethal watery diarrhea in piglets and poses a threat to public health because of its potential for interspecies transmission to humans. 25-Hydroxycholesterol (25HC), a deriv...

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Bibliographic Details
Main Authors: Jialu Zhang, Guanghui Yang, Xuefei Wang, Yaohong Zhu, Jiufeng Wang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
25-hydroxycholesterol
cholesterol metabolism
porcine deltacoronavirus
TGF-β1
lipid droplets
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02198-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02198-22

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