Accurate prediction of RNA secondary structure including pseudoknots through solving minimum-cost flow with learned potentials

Abstract Pseudoknots are key structure motifs of RNA and pseudoknotted RNAs play important roles in a variety of biological processes. Here, we present KnotFold, an accurate approach to the prediction of RNA secondary structure including pseudoknots. The key elements of KnotFold include a learned po...

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Bibliographic Details
Main Authors: Tiansu Gong, Fusong Ju, Dongbo Bu
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05952-w