Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Synapses are surrounded by an extracellular matrix (ECM) of extremely long-lived proteins that is thought to only be remodeled by proteolysis and de novo synthesis. Here, the authors show an alternative molecular recycling mechanism that occurs for the key ECM protein Tenascin-R.

Bibliographic Details
Main Authors: Tal M. Dankovich, Rahul Kaushik, Linda H. M. Olsthoorn, Gabriel Cassinelli Petersen, Philipp Emanuel Giro, Verena Kluever, Paola Agüi-Gonzalez, Katharina Grewe, Guobin Bao, Sabine Beuermann, Hannah Abdul Hadi, Jose Doeren, Simon Klöppner, Benjamin H. Cooper, Alexander Dityatev, Silvio O. Rizzoli
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27462-7

Internet

https://doi.org/10.1038/s41467-021-27462-7

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