SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry

SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid membrane to facilitate membrane fusion during entry is not fully understood. Here, using steady-state mem...

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Bibliographic Details
Main Authors: Puspangana Singh, Purba Pahari, Srija Mukherjee, Sharmistha Karmakar, Markus Hoffmann, Taraknath Mandal, Dibyendu Kumar Das
Format: Article
Language:English
Published: American Society for Microbiology 2024-09-01
Series:mBio
Subjects:
SARS-CoV-2
virus entry
conformational dynamics
membrane fusion
smFRET
lipid
Online Access:https://journals.asm.org/doi/10.1128/mbio.01077-24

Internet

https://journals.asm.org/doi/10.1128/mbio.01077-24

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