Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Abstract Background Old age, the most important risk factor for Alzheimer’s disease (AD), is associated with thermoregulatory deficits. Brown adipose tissue (BAT) is the main thermogenic driver in mammals and its stimulation, through β3 adrenergic receptor (β3AR) agonists or cold acclimation, counte...

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Bibliographic Details
Main Authors: Marine Tournissac, Tra-My Vu, Nika Vrabic, Clara Hozer, Cyntia Tremblay, Koralie Mélançon, Emmanuel Planel, Fabien Pifferi, Frédéric Calon
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
β3 adrenergic receptors
Drug repurposing
Thermogenesis
3xTg-AD mice
Brown adipose tissue
Online Access:https://doi.org/10.1186/s13195-021-00842-3

Internet

https://doi.org/10.1186/s13195-021-00842-3

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